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A CPR drive reached 200,000 people. A trial found no clear survival benefit

A randomized North Carolina trial found no significant improvement in survival with good brain function from a community and emergency-response training program.

U.S. Navy photo by Mass Communication Specialist 2nd Class Sasha Ambrose, public domain.

A program that missed its main goal

A five-year effort to train North Carolina communities and emergency responders did not significantly improve survival with good brain function after out-of-hospital cardiac arrest, according to results presented November 8 at the American Heart Association’s scientific meeting. The study tested a package of interventions—not whether CPR itself works.newsroom +1

Among adults who had a cardiac arrest outside a hospital, 9% in counties offered the program survived to hospital discharge with favorable brain function, compared with 9.4% in comparison counties. Researchers randomly assigned 31 counties to the program and 29 to continue their existing practices; the trial included 22,459 adults.newsroom

What the training tried to change

The program combined free community CPR education with training for 911 dispatchers to recognize cardiac arrest and coach callers, and efforts to improve first responders’ use of defibrillators. Over five years, 5,724 community training events reached 201,586 people, or 4.8% of residents in intervention counties.newsroom

One event in February 2026 brought training to 19,802 people across 30 counties in a single day, according to organizers cited by Duke’s student newspaper. It was part of the same trial, not a separate test of survival.dukechronicle

A late signal, not a proven solution

Across the full trial, bystanders gave CPR in 44.8% of arrests in intervention counties versus 42.3% in comparison counties; the overall difference was not statistically significant. An exploratory analysis of the final year found 33% higher odds of bystander CPR in intervention counties. That late finding warrants further study rather than demonstrating a survival benefit.newsroom +1

Counties varied in how extensively they implemented the program, and some training information was self-reported. Staffing turnover, the pandemic and Hurricane Helene also complicated implementation, the researchers said.newsroom

A 2020 review found community interventions were associated with better survival and bystander CPR rates, but most included studies were not randomized and programs varied widely. The new trial adds a randomized comparison for one specific approach; it does not settle which interventions might work elsewhere.jamanetwork

What to do in an emergency

Cardiac arrest means the heart suddenly stops beating; it is not the same as a heart attack. The CDC advises calling 911 immediately, looking for an automated external defibrillator and giving CPR until medical professionals arrive.cdc